Tag Archives: NEDD

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

The rapid development of new and emerging science & technologies (NESTs) brings unprecedented challenges, but also opportunities. In this paper, we use bibliometric and social network analyses, at country, institution, and individual levels, to explore the patterns of scientific networking for a key nano area – nano-enabled drug delivery (NEDD). NEDD has successfully been used clinically to modulate drug release and to target particular diseased tissues. The data for this research come from a global compilation of research publication information on NEDD directed at brain cancer. We derive a family of indicators that address multiple facets of research collaboration and knowledge transfer patterns. Results show that: (1) international cooperation is increasing, but networking characteristics change over time; (2) highly productive institutions also lead in influence, as measured by citation to their work, with American institutes leading; (3) research collaboration is dominated by local relationships, with interesting information available from authorship patterns that go well beyond journal impact factors. Results offer useful technical intelligence to help researchers identify potential collaborators and to help inform R&D management and science & innovation policy for such nanotechnologies.

Full-text article at http://www.beilstein-journals.org/bjnano/single/articleFullText.htm?publicId=2190-4286-6-169

author(s): Ying Huang, Jing Ma, Alan L Porter, Seokbeom Kwon, and Donghua Zhu
Organization(s): Beijing Institute of Technology
Source: Beilstein Journal of Nanotechnology
Year: 2015

Navigating the innovation trajectories of technology by combining specialization score analyses for publications and patents: graphene and nano-enabled drug delivery

In this study, we combine the specialization scores for publications and patents (the latter is a new indicator of cross-disciplinary engagement) to achieve more comprehensive navigation of the innovation trajectory of a technology. The patent specialization score draws upon counterpart research publication indicator concepts to measure patent diversity. Two nano-based technologies—Nano-enabled drug delivery (NEDD) and Graphene—provide contrasting explorations of the behavior of this indicator, alongside research publication indicators. Results show distinctive patterns of the two technologies and for the respective publication and patent indicators. NEDD research, as evidenced by publication and citation patterns, engages highly diverse research fields. In contrast, NEDD development, as reflected in patent International Patent Classifications (IPCs), concentrates on relatively closely associated fields. Graphene presents the opposite picture, with closely linked disciplines contributing to research, but much more diverse fields of application for its patents. We suggest that analyzing the field diversity of research publications and patents together, employing both specialization scores, can offer fruitful insights into innovation trajectories. Such information can contribute to technology and innovation management and policy for such emerging technologies.


Author(s): Seokbeom Kwon, Alan Porter, Jan Youtie
Organization(s): Georgia Institute of Technology
Source: Scientometrics
Year: 2016

Nano-enabled drug delivery systems for brain cancer and Alzheimer’s disease: research patterns and opportunities

“Tech mining” applies bibliometric and text analytic methods to scientific literature of a target field. In this study, we compare the evolution of nano-enabled drug delivery (NEDD) systems for two different applications – viz., brain cancer (BC) and Alzheimer’s disease (AD) – using this approach. In this process, we derive research intelligence from papers indexed in MEDLINE. Review by domain specialists helps understand the macro-level disease problems and pathologies to identify commonalities and differences between BC and AD. Results provide a fresh perspective on the developmental pathways for NEDD approaches that have been used in the treatment of BC and AD. Results also point toward finding future solutions to drug delivery issues that are critical to medical practitioners and pharmaceutical scientists addressing the brain.

FROM THE CLINICAL EDITOR: Drug delivery to brain cells has been very challenging due to the presence of the blood-brain barrier (BBB). Suitable and effective nano-enabled drug delivery (NEDD) system is urgently needed. In this study, the authors utilized “tech-mining” tools to describe and compare various choices of delivery system available for the diagnosis, as well as treatment, of brain cancer and Alzheimer’s disease.


Author(s): Jing Ma, Alan Porter, TM Aminabhavi, Donghua Zhu
Organization(s): Beijing Institute of Technology, Georgi
Source: Nanomedicine
Year: 2015

Tech Mining to Generate Indicators of Future National Technological Competitiveness: Nano-enhanced Drug Delivery (NEDD) in the US and China

“Global technological competitiveness” is widely acknowledged, but the challenge is to go beyond this recognition to develop empirical indicators of important transitions. These may concern particular technologies, the competitive position of particular organizations, or national/regional shifts. For decades, the US has been the world leader in biomedical technologies, with attendant implications for organizational priorities in terms of R&D location and market targeting. Recent years have seen a tremendous acceleration in Asian research in most domains, including biomedical, particularly visible in China. This paper investigates comparative patterns between the US and China in a promising emerging area of biotechnology — Nano-Enhanced Drug Delivery. It then explores indicators of, and implications for, future transitions at the national level — an approach we label “Forecasting Innovation Pathways.” http://www.sciencedirect.com/science/article/pii/S0040162514000900 Highlights

  • Tech mining generates indicators for future national technological competitiveness.
  • The case is a promising emerging area of biotechnology — Nano-Enhanced Drug Delivery.
  • We investigate comparative patterns between the US and China.
  • Results can provide insight into the approach of “Forecasting Innovation Pathways.”

Author(s): Ying Guo, Xiao Zhou, Alan L. Porter, and Douglas K.R. Robinson Organization(s): Beijing Instititute of Technology, Georgia Institute of Technology, Université de Paris-Est Source: Technological Forecasting & Social Change Year: 2015

Analyzing patent topical information to identify technology pathways and potential opportunities

As a basic knowledge resource, patents play an important role in identifying technology development trends and opportunities, especially for emerging technologies. However patent mining is restricted and even incomplete, because of the obscure descriptions provided in patent text. In this paper, we conduct an empirical study to try out alternative methods with Derwent Innovation Index data. Our case study focuses on nano-enabled drug delivery (NEDD) which is a very active emerging biomedical technology, encompassing several distinct technology spaces. We explore different ways to enhance topical intelligence from patent compilations. We further analyze extracted topical terms to identify potential innovation pathways and technology opportunities in NEDD.

Author(s): Jing Ma and  Alan L. Porter
Organization(s): Beijing Institute of Technology and Georgia Institute of Technology
Source: Scientometrics
Year: 2014