Over 15,000 articles and reviews published since 2000 were collected, with genome editing-related queries in the Web of Science (Table 1 and Supplemental Table S1). We use tech mining to investigate the underlying patterns that drive the adoption of genome editing, proposing an integrated research framework with bibliometrics, text analyses, and network analysis to analyze publication trends, authorship patterns, and key research topics and technologies of the genome editing field and provide quantitative and qualitative insights into the drivers of the CRISPR craze. Of the literature on gene-editing modalities, CRISPR-Cas continues to grow, whereas publications describing meganucleases, zinc-finger nucleases, and transcription activator-like effector nuclease (TALENs) have been decreasing since 2016. The top 5 nations contributing gene-editing research are the United States, China, Germany, the United Kingdom, and Japan, with papers from China growing fastest. A diverse set of collaborative authors provides both leadership in the field and globalized contributions to the literature across space, time, and disciplines. The collaborative nature of this field is underscored by each of the 15 leading authors in the field (Table 2), all working with at least one fellow leading author, with 10 of the 15 co-authoring manuscripts with at least 2 other leading authors, and 4 highly collaborative authors contributing manuscripts with three or more prolific colleagues.
Author(s): Ying Huang, Alan Porter, Yi Zhang & Rodolphe Barrangou
Organization(s): Wuhan University, Georgia Institute of Technology, University of Technology Sydney, North Carolina State University
Source: Nature Biotechnology (Data Page)