Category Archives: Research profiling

A Strategic View for Rare Earths Production, in a Competitive and Sustainable form

The demand for rare earths (RE) has been intensified by their large use, especially in high technology sectors. Supply difficulties have forced RE users to seek alternative sources and invest in the development of recycling technologies and options of reuse for these elements. This article seeks to reveal the trends and ongoing changes in national and global prospects of RE. Additionally, it aims to analyze scientific collaboration networks in the area of industrial solid waste (ISW) and waste electrical and electronic equipment (WEEE) exploitation in Brazil, examining both researchers and institutions with greater representation in the field. For this purpose, social network analysis methods were used to build and analyze co-authorship networks based on scientific publications retrieved from the Web of Science (WoS) database. The results showed that the Brazilian collaboration network of ISW research was extremely fragmented and contained 105 different groups, which were not connected to each other. The institutional network of ISW research was composed of 125 institutions, 75.2% of them from Brazil. The Brazilian collaboration network of research in WEEE was small (37 researchers), but fragmented: researchers were divided into eight different groups that do not connect to each other. The institutional network of research in WEEE was composed by 12 institutions, nine of them from Brazil. Therefore, this article presents a network collaboration model to bring together actors involved in the management of waste electrical and electronic equipment (WEEE), emphasizing the potential for recovery of RE from these wastes, with the purpose of developing products and services.

For FULL-TEXT of article, go to

http://www.ccsenet.org/journal/index.php/enrr/article/viewFile/64760/34921

Author(s): Tereza Raquel Taulois Campos, Marcus Vinícius de Araújo Fonseca, Bruna de Paula Fonseca e Fonseca, Edison de Oliveira Martins
Organization(s): Nuclear Engineering Institute, Federal University of Rio de Janeiro, Oswaldo Cruz Foundation
Source: Environment and Natural Resources Research
Year: 2016

Four decades of coupon research in pricing: Evolution, development, and practice

Coupons are a sales promotion tool frequently used by marketers. While considerable research has been conducted on coupons such as its profitability, design, and redemption rate for increased sales, few attempts have been made to summarize the published literature in the form of a review. This paper presents a comprehensive evaluation of research on coupons over the last four decades by examining the evident patterns via keywords, research themes, coupon types, and countries where the studies are based, authors, journals, and product categories utilizing coupon schemes. This mapping of the literature clarifies the evolution of research on coupons and identifies potential developments related to aspects such as coupon design and framing. More importantly, it contributes to the future research agenda by identifying gaps in extant knowledge and evidence.

http://link.springer.com/article/10.1057/s41272-016-0076-7

Author(s): Neeraj Pandey, Vaibhav Maheshwari
Organization(s): National Institute of Industrial Engineering (NITIE)
Source: Journal of Revenue and Pricing Management
Year: 2016

Building a View of the Future of Antibiotics Through the Analysis of Primary Patents

The primary patent application of a new drug is the application that claims the chemical structure of that new compound and is usually the first patent filled regarding that new drug. Therefore, the analysis of the recent primary patents in a therapeutic group reflects the results of the research toward finding new compounds and allows building a view of the future of that therapeutic class. The identification of the primary patents is challenging and requires data treatment, visualization, and analysis tools. In order to address this matter, this paper presents a method for gathering and analyzing the primary patent applications for new antibiotics using the VantagePoint software. This therapeutic class was chosen due to the continuous rise of resistant bacteria, the critical need for new antibiotics that, combined with the lack new drugs in the market, leads to an urgent need for public and private policies to improve research in the field. The method resulted in 1333 primary patent applications of new antibiotics that were analyzed regarding the discovery strategy, the chemical classes, and mechanisms of action and according to the bacteria for which they are active. This analysis was made using different VantagePoint resources and allowed view of the new compounds that might reach the market in the future.

Author(s): Cristina d’Urso de Souza Mendes and Adelaide Maria de Souza Antunes
Organization(s): Federal University of Rio de Janeiro (UFRJ), Brazilian National Institute of Industrial Property (INPI)
Source: Anticipating Future Innovation Pathways Through Large Data Analysis pp 303-320
Year: 2016

Nano-enabled Drug Delivery in Cancer Therapy: Literature Analysis Using the MeSH System

Biomedical literature provides abundant knowledge on R&D development and emerging themes and techniques to researchers and to enhance clinical treatment. Tracing research topic activity and researcher connections, and understanding evolving research landscapes, supports identification of research domain potential and informs R&D portfolio management. Methods: We offer a systematic approach to summarize biomedical research information compiled from the MEDLINE database. Selected MeSH qualifiers are applied as properties for clustering terms. Linkages among clusters are measured based on an object–attribute–value, relative research concentration. By arraying selected technical dimensions against each other, we enable identification and evaluation of latent connections. Results: 10354 MEDLINE records from 2000 to 2013 on nano-enabled drug delivery (NEDD) for cancer treatment are retrieved and analyzed. Seven topical clusters are generated with relatively clear boundaries. Elements with high relative research concentration but low number of records show emerging trends. And the concentrations’ decline indicates the universalization of drugs and nano components in cancer treatment. Conclusions: This systematic topical analysis process helps explore particular technological trends and potentials in biomedical areas. It combines an algorithm to reveal latent connections hidden in literature text content with expert judgement. From the standpoint of technology assessment, it provides researchers and administrators the ability to capture biomedical research dynamics.

http://www.eurekaselect.com/144824/article

Author(s): Tejraj M Aminabhavi, Jing Ma and Alan L Porter
Organization(s): Shree Dhanvantary Pharmacy College
Source: Pharmaceutical Nanotechnology
Year: 2016

A systematic review of studies on leadership models in educational research from 1980 to 2014

The purpose of this study is to reveal the extent to which different leadership models in education are studied, including the change in the trends of research on each model over time, the most prominent scholars working on each model, and the countries in which the articles are based. The analysis of the related literature was conducted by first employing a bibliometric analysis of the research and review papers indexed in the Web of Science database between 1980 and 2014. Then, a more in-depth analysis of selected papers was done using the content analysis method. The results showed that there has been increasing interest in leadership models in educational research over time. Distributed leadership, instructional leadership, teacher leadership, and transformational leadership are the most studied leadership models in educational research. It was also found that related research increasingly focuses on the effects of leaders on organizational behaviors/conditions and on student achievement. Accordingly, usage of quantitative methodology has significantly increased during the last decade. Possible reasons for these changes, implications, and recommendations for future research are also discussed.

http://ema.sagepub.com/content/early/2016/09/22/1741143216659296.abstract

Author(s): Sedat Gumus, Mehmet Sukru Bellibas, Murat Esen, Emine Gumus
Organization(s): Necmettin Erbakan Universitesi
Source: Educational Management Administration & Leadership
Year: 2016

A bibliometric analysis of the development of next generation active nanotechnologies

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

http://link.springer.com/article/10.1007/s11051-016-3578-8

Author(s): Arho Suominen, Yin Li, Jan Youtie, Philip Shapira
Organization(s): Georgia Institute of Technology, University of Manchester, VTT Technical Research Centre of Finland
Source: Journal of Nanoparticle Research
Year: 2016

Lessons from Ten Years of Nanotechnology Bibliometric Analysis

This paper summarizes the 10-year experiences of the Program in Science, Technology, and Innovation Policy (STIP) at Georgia Institute of Technology (Georgia Tech) in support of the Center for Nanotechnology in Society at Arizona State University (CNS-ASU) in understanding, characterizing, and conveying the development of nanotechnology research and application. This work was labeled “Research and Innovation Systems Assessment” or (RISA) by CNS-ASU.

RISA concentrates on identifying and documenting quantifiable aspects of nanotechnology, including academic, commercial/industrial, and government nanoscience and nanotechnology (nanotechnologies) activity, research, and projects. RISA at CNS-ASU engaged in the first systematic attempt of its kind to define, characterize, and track a field of science and technology. A key element to RISA was the creation of a replicable approach to bibliometrically defining nanotechnology. Researchers in STIP, and beyond, could then query the resulting datasets to address topical areas ranging from basic country and regional concentrations of publications and patents, to findings about social science literature, environmental, health, and safety research and usage, to study corporate entry into nanotechnology, and to explore application areas as special interests arose. Key features of the success of the program include:

  • Having access to “large-scale” R&D abstract datasets
  • Analytical software
  • A portfolio that balances innovative long-term projects, such as webscraping to understand nanotechnology developments in small and medium-sized companies, with research characterizing the emergence of nanotechnology that more readily produces articles
  • Relationships with diverse networks of scholars and companies working in the nanotechnology science and social science domains
  • An influx of visiting researchers
  • A strong core of students with social science, as well as some programming background
  • A well-equipped facility and management by the principals through weekly problem-solving meetings, mini-deadlines, and the production journal articles rather than thick final reports.

https://smartech.gatech.edu/handle/1853/55931?show=full

Author(s): Jan Youtie, Alan Porter, Philip Shapira, Nils Newman
Organization: Georgia Institute of Technology
Source: OECD Blue Sky Forum on Science and Innovation Indicators
Year: 2016

A bibliometric analysis of 50 years of worldwide research on statistical process control

An increasing number of papers on statistical process control (SPC) has emerged in the last fifty years, especially in the last fifteen years. This may be attributed to the increased global competitiveness generated by innovation and the continuous improvement of products and processes. In this sense, SPC has a fundamentally important role in quality and production systems. The research in this paper considers the context of technological improvement and innovation of products and processes to increase corporate competitiveness. There are several other statistical technics and tools for assisting continuous improvement and innovation of products and processes but, despite the limitations in their use in the improvement projects, there is growing concern about the use of SPC. A gap between the SPC technics taught in engineering courses and their practical applications to industrial problems is observed in empirical research; thus, it is important to understand what has been done and identify the trends in SPC research. The bibliometric study in this paper is proposed in this direction and uses the Web of Science (WoS) database. Data analysis indicates that there was a growth rate of more than 90% in the number of publications on SPC after 1990. Our results reveal the countries where these publications have come from, the authors with the highest number of papers and their networks. Main sources of publications are also identified; it is observed that the publications of SPC papers are concentrated in some of the international research journals, not necessarily those with the major high-impact factors. Furthermore, the papers are focused on industrial engineering, operations research and management science fields. The most common term found in the papers was cumulative sum control charts, but new topics have emerged and have been researched in the past ten years, such as multivariate methods for process monitoring and nonparametric methods.

http://www.scielo.br/scielo.php?pid=S0104-530X2016005013101&script=sci_arttext&tlng=en

Author(s): Fabiane Letícia Lizarelli, Nayara Cristini Bessi, Pedro Carlos Oprime , Roniberto Morato do Amaral, Subhabrata Chakraborti
Organization(s): Universidade Federal de São Carlos – UFSCar
Source: Gestão & Produção
Year: 2016

Case study of patents related to captopril, Squibb’s first blockbuster

Arterial hypertension affects over one billion people around the world, making the prevention and treatment of this disease vital. Despite the efforts made to develop new antihypertensive drugs, few new therapies have become available. Angiotensin-converting enzyme (ACE) inhibitors have heralded major steps forward in the treatment of arterial hypertension and cardiovascular diseases since the first compound of this class, captopril, was approved for clinical use in 1981.

In this review, the authors investigated the patent documents that cite the priority patent for captopril, Squibb’s first blockbuster, or any other patent from its patent family. The documents were classified into the following: new compounds, new compositions, treatment, process (preparation of a compound), use of a compound, and process for the preparation of an intermediate. Therefore, the readers can identify potential innovations in the field.

The pharmaceutical sector has attempted to provide significant technological developments on anti-hypertensive drugs based on the patenting of captopril, including the development of new compositions further comprising an ACE inhibitor and other antihypertensive agent, along with dual action compounds, novel molecules with dual activity. The target is to find a new agent with better blood pressure-lowering efficacy, improved safety and good tolerability profile.

http://www.tandfonline.com/doi/abs/10.1080/13543776.2016.1227321

Author(s): Adelaide Maria de Souza Antunes, Rafaela Di Sabato Guerrante, Jorge de Paula Costa Ávila, Flavia Maria Lins Mendes
Organization(s): Federal University of Rio de Janeiro (UFRJ)/National Institute of Industrial Property (INPI-Brazil)
Source: Expert Opinion on Therapeutic Patents
Year: 2016

Xylose utilization in ethanol production: a patent landscape

Bioethanol is considered as one of the best alternatives to fossil fuels as unwanted biomass is converted into fuel ethanol. As there is increasing demand for fuel ethanol, researchers have started looking for some better ways to produce ethanol. In light of the present scenario, we have attempted to develop a global patent landscape view of xylose utilization in ethanol production. Our country-specific patent analysis has revealed that most of the research on xylose-utilizing ethanol production is carried out in the USA followed by China and Sweden. Moreover, it has been found that more patent applications/grants have been claimed for processes, followed by recombinant strains. Patent publication trends for genes and enzymes have shown that most of the research is focused on the xylA gene and xylulokinase. Assignee patenting trends suggest that Du Pont is the major player in xylose-utilizing ethanol production research. Additionally, analysis based on micro-organisms used in xylose-utilizing ethanol production revealed that most of the research has been performed using Saccharomyces cerevisiae to enhance the ethanol yields.
http://onlinelibrary.wiley.com/doi/10.1002/bbb.1664/full

Author(s): Pratap Devarapalli, Nishad Deshpande, Rajkumar R Hirwani
Organization(s): CSIR-Unit for Research and Development of Information Products
Source: Biofuels, Bioproducts and Biorefining
Year: 2016